Women with Autoimmune Thyroiditis have Lower Reproductive Life Span or Not? A Cross- Sectional Study

Alamtaj Samsami, Alamtaj Samsami and Leila Ghasmpour, Leila Ghasmpour and Shaghayegh Moradi Alamdarloo, Shaghayegh Moradi Alamdarloo and Sara Davoodi, Sara Davoodi and Jamshid Rahmati, Jamshid Rahmati and Ali Karimian, Ali Karimian and Mona Tavasoli, Mona Tavasoli (2020) Women with Autoimmune Thyroiditis have Lower Reproductive Life Span or Not? A Cross- Sectional Study. International Journal of Community Based Nursing and Midwifery, 8 (32). pp. 305-310. ISSN pISSN: 2322-2476 eISSN: 2322-4835

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Abstract

Background: Autoimmune diseases are a main cause of primary ovarian insufficiency. This study was designed to elucidate the relationship between ovarian reserve and anti-thyroid peroxidase antibodies in women of different ages.
Methods: 98 women in a cross-sectional study was conducted at the infertility Center of Shiraz University of Medical Sciences, Hazrate Zeinab Hospital, from September 2018 to March 2019. Women with infertility and thyroid-stimulating hormone (TSH) > 3mIU/L were included in the study with convenience sampling. Data were collected by a form containing demographic characteristics, thyroid hormones, and ovarian reserve data. Participants were categorized based on the negative or positive anti-thyroid peroxidase (anti-TPO) antibodies. According to a pilot sample, and possible dropout of 20%, the sample size was determined to be 49 cases in each group. The results were compared between groups using SPSS, version 22. All statistical comparisons were performed using the t-test, and the data are presented as the mean±SD. P-values less than 0.05 were considered significant.
Results: 49 women were analyzed in each group. There was no significant difference between the groups in the mean age (P=0.42), body mass index (BMI) (P=0.34), duration of infertility (P=0.99), mean prolactin (P=0.66), TSH (P=0.17), thyroxine (T4) (P=0.87) and follicle-stimulating hormone (FSH) levels (P=0.14). Ovarian reserve characteristics: antral follicular count (AFC) and anti-Müllerian hormone (AMH) levels in anti-TPO positive group were 10.61±7.29 and 1.98±2.38, respectively, and AFC and AMH in anti- TPO negative group were 16.46±6.38 and 2.94±2.22, respectively. There were significant differences between the two groups on AFC (P <0.001) and AMH (P=0.04).
Conclusion: Patients with autoimmune thyroiditis were at higher risk for decreased ovarian reserve. They should consider their lower reproductive life span during their childbearing years.

Item Type:	Article
Uncontrolled Keywords:	Female infertility, Hashimoto disease, Anti-Müllerian hormone, Ovarian reserve
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User:	Mrs Ni Made Yunia Dwi Savitri
Date Deposited:	04 Jul 2022 00:45
Last Modified:	04 Jul 2022 00:45
URI:	http://eprints.triatmamulya.ac.id/id/eprint/1274

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